British Division of the International Academy of Pathology

Symposium on Gynaecological Pathology

Sheffield. September 1999

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Diagnoses and references for the Slide Seminar are below.

09.30-10.00 Angiogenesis and the Prospects for Gene Therapy in Ovarian Cancer

Prof Steve Smith, Cambridge

10.00-10.30 Diagnostic Dilemmas in Ovarian Tumour Pathology

Dr Terry Rollason, Birmingham

10.30-11.00 Molecular Pathology of Endometrial Cancer

Prof Jaime Prat, Barcelona

11.30-12.00 Hormone Replacement Therapy and the Endometrium

Prof Michael Wells, Sheffield

12.00-13.00 Advances in Endometrial Pathology

Dr Dwayne Lawrence, Detroit

14.00-14.30 Human Papilloma Viruses and Cervical Pathology

Dr Simon Herrington, Liverpool

14.30-15.00 The Pathology of Hydatidiform Mole

Prof Ferrnando Paradinas, London

15.00-15.30 Soft Tissue Tumours of the Lower Female Genital Tract

Dr Marisa Nucci, Boston

16.00-17.00 Litigation and the Gynaecological Pathologist as Expert Witness

Prof Harold Fox, Manchester

Ms Stephanie Forman, Head of Medical Negligence, Donns Solicitors, Manchester

SLIDE SEMINAR

Slide Seminar Contributors:

Dr A Al-Nafussi (Edinburgh)

Dr M Heatley (Liverpool)

Dr S Manek (Oxford)

Dr W G McCluggage (Belfast)

Dr J H Smith (Sheffield)

Dr N Wilkinson (Leeds)

1) Metastatic spindle cell carcinoid in the ovary.

Ulbright TM et al. Secondary ovarian neoplasia. A clinicopathologic study of 35 cases. Cancer 1984; 53; 1164-1174

Brown BL et al. Bronchial carcinoid tumour with ovarian metastasis. A light microscopic and ultrastructural study. Cancer 1980; 46; 543-546.

2) Mucinous carcinoma with endometriod differentiation and ovarian type stroma? originating in a reduplication cyst.

A unique case for which there are no specific references. However accounts of reduplication cysts can be found in:

Morson BC, Dawson IMP. Morson & Dawson's Gastrointestinal Pathology. Blackwell Scientific Publications. 3rd Edition. 1990. p 221 & 446.

Whitehead R (Ed). Gastrointestinal and Oesophageal Pathology. Churchill Livingstone 1989. p 234 & 245-246.

3) Burkitt’s lymphoma of the ovary.

Chan JKC, Banks PM, Cleary ML. et al A proposal for classification of lymphoid neoplasms (by the international lymphoma study group). Histopathology 1994, 25: 517-536.

Fox H, et al. Malignant lymphoma presenting as an ovarian tumour: a clinicopathological analysis of 34 cases. Br J Obstet Gynaecol 1988 95(4): 386-390.

Monterroso V, Jaffe ES, Merino MJ, Medeiros LJ. Malignant lymphomas involving the ovary: a clinicopathological analysis of 39 cases. Am J Surg Pathol 1993 17(2): 154-170.

Neary B, Young SB, Reuter KL. Ovarian Burkitt lymphoma: pelvic pain in a woman with AIDS. Obstet Gynecol 1996 88(4): 706-708.

4. Serous papillary carcinoma of the endometrium.

Ambros RA, Sherman ME, Zahn CM et al, Endometrial intraepithelial carcinoma: a distinctive lesion specifically associated with tumors displaying serous differentiation. Hum Pathol 1995 26(11): 1260-1267.

Burton JL, Wells M. Recent advances in the pathology of endometrial carcinoma. CPD Bulletin Cellular Pathology 1998, (1): 3-5.

Carcangiu ML, Tan LK, and Chambers JT. Stage 1A uterine serous carcinoma: a study of 13 cases. Am J Surg Pathol 1997; 21(12): 1507-1514.

Kennedy MM, Baigrie CF, Manek S. Tamoxifen and the endometrium: review of 102 cases and comparison with HRT-related and non-HRT-related endometrial pathology. Int J Gynecol Pathol 1999; 18: 130-137.

Silva Elvio G, Tornos CS, Follen-Mitchell M. Malignant neoplasms of the uterine corpus in patients treated for breast carcinoma: the effects of tamoxifen. Int J Gynaecol Pathol 1994 13 248-258.

5 Endometriosis with stromal myxoid change and decidualisation.

Clement PB et al. Endometriosis with myxoid change: a case simulating pseudomyxoma peritonei. Am J Surg Pathol 1994; 18: 849-853.

Hameed et al. Endometriosis with myxoid change simulating mucinous adenocarcinoma and pseudomyxoma peritonei. Gynecol Oncol 1996; 62: 317-319.

Ying et al. Myxoid change in nondecidualised endometriosis resembling malignancy. Gynecol Oncol 1998; 68; 301-303.

6) Uterine adenolipoleiomyoma.

Payne et al. Adenomyolipoma of the endometrium: a hamartoma? Histopathology 1992; 20: 357-359.

7) Endometrial stromal sarcoma with glandular elements.

Clement PB, Scully RE. Endometrial stromal sarcomas of the uterus with extensive endometrioid glandular differentiation: a report of three cases that caused problems in differential diagnosis. Int J Gynecol Pathol 1992; 11:163-173.

Clement PB, Scully RE. Uterine tumours with mixed epithelial andmesenchymal elements. Seminars in Diagnostic Pathology 1988; 5(2): 199-222.

8) Neurogenic sarcoma.

Bernstein HB, Broman JH, Apicelli A, Kredenster DC. Primary malignant Schwannoma of the uterine cervix: a case report and literature review. Gynecologic Oncology 1999; 74:288-292.

Vauthey J-N, Woodruff JM, Brennan MF. Extremity malignant peripheral nerve sheath tumours (neurogenic sarcomas): a 10-year experience. Annals of Surgical Oncology 1995; 2(2):126-131.

9) Florid cystic endosalpingiosis.

Clement PB, Young RH. Florid cystic endosalpingiosis with tumour like manifestations. Am J Surg Pathol 1999; 23: 166-175.

10) Adenomatous hyperplasia of the rete ovarii.

Rutgers JL, Scully RE. Cysts (cystadenomas) and tumours of the rete ovarii. Int J Gynecol Pathol 1988; 7: 330-342.

11) Transitional cell carcinoma of the cervix with transitional cell metaplasia.

Albores-Saavedra J, Young RH. Transitional cell neoplasms (carcinomas and inverted papillomas) of the uterine cervix. A report of five cases. Am J Surg Pathol 1995; 19: 1138-1145.

Raed A, Sulaiman R, Manivel J. Papillary transitional carcinoma (TCC) of the uterine cervix and its histological mimics. Mod Pathol 1996; 9: 98A.

Koenig C, Turnicky R, Kankam C, Tavassoli F. Papillary squamotransitional cell carcinoma of the cervix: a report of 32 cases. Am J Surg Pathol 1997; 21: 915-921.

Fukunaga M. Inverted papilloma-like transitional cell carcinoma of the uterine cervix. Histopathology 1998; 33: 184-194.

Egan AJM, Russell P. Transitional (urothelial) cell metaplasia of the uterine cervix: morphological assessment of 31 cases. Int J Gynecol Pathol 1997; 16: 89-98.

Weir MM, Bell DA, Young RH. Transitional cell metaplasia of the uterine cervix and vagina: an underrecognised lesion that may be confused with high grade dysplasia. A report of 59 cases. . Am J Surg Pathol 1997; 21: 510-517.

Jones MA. Transitional cell metaplasia and neoplasia in the female genital tract: an update. Adv in Anat Pathol 1998; 5: 106-113

12) Strumosis peritonei.

Emge LA. Functional and growth characteristics of struma ovarii. Am J Obst & Gynecol 1940; 40: 477-480.

Kragel PJ et al. Struma ovarii with peritoneal implants: a case report with lectin histochemistry. Surg Pathol 1991; 4: 274-281.

Tennvall J, Ljungberg O, Hogberg T. Malignant struma ovarii with peritoneal dissemination. Histopathology 1997; 31: 289-290.

Devaney K et al. Proliferative and histologically malignant struma ovarii: a clinicopathologic study of 54 cases. Int J Gynecol Pathol 1993; 12: 333-343.

Robboy SJ et al. Prognostic indices in malignant struma ovarii: clinicopathologic analysis of 36 patients with 20+ years follow up. Mod Pathol 1995; 8: 95A